# The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice

*PRI Rank #9 · Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 45 |
| Journal | Nature Metabolism |
| Year | 2024 |
| DOI | 10.1038/s42255-024-01041-8 |
| Corresponding authors | Rong Li, Changtao Jiang, Jie Qiao, Yanli Pang |
| Institution | Peking University Third Hospital, China |

**Ranking page:** [Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026](https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026)

**Paper link:** [10.1038/s42255-024-01041-8](https://doi.org/10.1038/s42255-024-01041-8)

## Topics

agmatine · FXR agonist · Polycystic ovary syndrome · microbial metabolite · gut microbiota · farnesoid X receptor · PCOS mouse model · microbiome-host interaction · metabolite signaling · nuclear receptor activation · ovarian dysfunction · gut-ovary axis · bacterial metabolism · Endocrine disruption

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026. https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```