# Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses

*PRI Rank #4 · Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 65 |
| Journal | Nature Aging |
| Year | 2024 |
| DOI | 10.1038/s43587-024-00762-5 |
| Corresponding authors | Chen Jin, Yousin Suh |
| Institution | Columbia University Irving Medical Center, United States |

**Ranking page:** [Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026](https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026)

**Paper link:** [10.1038/s43587-024-00762-5](https://doi.org/10.1038/s43587-024-00762-5)

## Topics

single-nuclei multi-omics · Female reproductive aging · single-nuclei RNA-seq · single-nuclei ATAC-seq · chromatin accessibility · mTOR signaling · CEBPD transcription factor · Age at menopause · cell-type-specific regulatory networks · non-coding regulatory variants · gene regulatory networks · reproductively aged ovaries · Female reproductive aging · epigenomic changes · functional genetic variants · Ovarian cell atlas · transcriptomic aging signatures · menopause-associated variants · ovary-specific aging pathways

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026. https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```