# Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1

*PRI Rank #2 · Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 67 |
| Journal | Nature Aging |
| Year | 2024 |
| DOI | 10.1038/s43587-024-00607-1 |
| Corresponding authors | Jun Dai, Yan Li, Tao Xiang, Shixuan Wang |
| Institution | Huazhong University of Science and Technology, China |

**Ranking page:** [Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026](https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026)

**Paper link:** [10.1038/s43587-024-00607-1](https://doi.org/10.1038/s43587-024-00607-1)

## Topics

Single-cell transcriptomics · spatial transcriptomics · Female reproductive aging · Oocyte aging · DNA damage response · granulosa cells subtypes · theca and stromal cells subtypes · FOXP1 · CDKN1A transcription · Premature ovarian insufficiency · Spatiotemporal transcriptomics · age-associated gene expression · Ovarian cell atlas · FOXP1 silencing

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026. https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```