# Semaglutide Alleviates Ovary Inflammation via the AMPK/SIRT1/NF‑κB Signaling Pathway in Polycystic Ovary Syndrome Mice

*PRI Rank #18 · Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 32 |
| Journal | Drug Design Development and Therapy |
| Year | 2024 |
| DOI | 10.2147/dddt.s484531 |
| Corresponding authors | Mei Liu, Sili Guo, Xiaohan Li |
| Institution | Binzhou Medical University Hospital, China |

**Ranking page:** [Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026](https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026)

**Paper link:** [10.2147/dddt.s484531](https://doi.org/10.2147/dddt.s484531)

## Topics

semaglutide · GLP-1 receptor agonists · Polycystic ovary syndrome · ovarian inflammation · AMPK/SIRT1/NF-κB signaling pathway · dehydroepiandrosterone · C57BL/6 mice · CYP19A1 · CYP17A1 · StAR · TNF-α · IL-6 · IL-1β · NF-κB · AMPK phosphorylation · SIRT1 · IκBα phosphorylation · insulin resistance · follicular cystic dilation · Estrous cycle

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026. https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```