# M6A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis

*PRI Rank #17 · Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 33 |
| Journal | Journal of Nanobiotechnology |
| Year | 2024 |
| DOI | 10.1186/s12951-024-02583-5 |
| Corresponding authors | Xiaolan Zhu |
| Institution | The Fourth Affiliated Hospital of Jiangsu University, China |

**Ranking page:** [Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026](https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026)

**Paper link:** [10.1186/s12951-024-02583-5](https://doi.org/10.1186/s12951-024-02583-5)

## Topics

Premature ovarian insufficiency · human umbilical cord mesenchymal stem cell-derived exosomes · circBRCA1 · FTO · m6A demethylation · miR-642a-5p · FOXO1 · Granulosa cells · oxidative stress · mitochondrial dysfunction · ovarian reserve function · Follicular depletion · Reactive oxygen species · senescence-associated β-galactosidase staining · competing endogenous RNA · Estrous cycle · reproductive hormones · oxygen consumption rate · Gene Expression Omnibus database

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026. https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```