# Maintaining mitochondrial DNA copy number mitigates ROS-induced oocyte decline and female reproductive aging

*PRI Rank #16 · Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 33 |
| Journal | Communications Biology |
| Year | 2024 |
| DOI | 10.1038/s42003-024-06888-x |
| Corresponding authors | Yanmei Dou, Min Jiang |
| Institution | Zhejiang University, China |

**Ranking page:** [Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026](https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026)

**Paper link:** [10.1038/s42003-024-06888-x](https://doi.org/10.1038/s42003-024-06888-x)

## Topics

mitochondrial DNA copy number · Reactive oxygen species · oocyte maturation · Female reproductive aging · Sod2 conditional knockout · primordial follicles · mitochondrial matrix ROS · OXPHOS complex II · mtDNA-encoded mRNA · mtDNA mutation load · mtSSB protein · mtDNA replication · oxidative stress · oocyte quality · maternal mtDNA transmission · Female reproductive aging

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026. https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```