# Iron accumulation in ovarian microenvironment damages the local redox balance and oocyte quality in aging mice

*PRI Rank #14 · Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 34 |
| Journal | Redox Biology |
| Year | 2024 |
| DOI | 10.1016/j.redox.2024.103195 |
| Corresponding authors | Wei Ma |
| Institution | Capital Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026](https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026)

**Paper link:** [10.1016/j.redox.2024.103195](https://doi.org/10.1016/j.redox.2024.103195)

## Topics

iron accumulation · Ovarian microenvironment · oocyte quality · ovarian reserve decline · heme oxygenase 1 (HO-1) · ferritin heavy chain (FTH) · ferritin light chain (FTL) · mitochondrial ferritin (FTMT) · divalent metal transporter 1 (DMT1) · ferroportin1 (FPN1) · iron regulatory proteins (IRP1 and IRP2) · transferrin receptor 1 (TFR1) · ferritinophagy · mitophagy · lipid peroxidation · mitochondrial dysfunction · deferoxamine (DFO) · iron chelation · oocyte aneuploidy · Female reproductive aging

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026. https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```