# A single-cell atlas of the aging mouse ovary

*PRI Rank #1 · Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 89 |
| Journal | Nature Aging |
| Year | 2024 |
| DOI | 10.1038/s43587-023-00552-5 |
| Corresponding authors | Michael B. Stout |
| Institution | Oklahoma Medical Research Foundation, United States |

**Ranking page:** [Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026](https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026)

**Paper link:** [10.1038/s43587-023-00552-5](https://doi.org/10.1038/s43587-023-00552-5)

## Topics

Female reproductive aging · Single-cell transcriptomics · Mouse ovary · oocyte quality · immune cell infiltration · lymphocyte accumulation · flow cytometry · stromal fibroblasts · collagenase pathway downregulation · Ovarian fibrosis · follicular cells · Cellular stress responses · immunogenic signaling · fibrotic signaling · reproductively aged mice · transcriptomic changes · Follicular depletion · Shiny-based web application

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Reproductive Biology and Fertility Papers, Class of 2026. https://pri.pepkio.com/top-papers/reproductive-biology-and-fertility/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```