# AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors

*PRI Rank #6 · Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 77 |
| Journal | Acta Pharmacologica Sinica |
| Year | 2024 |
| DOI | 10.1038/s41401-024-01429-y |
| Corresponding authors | H. Eric Xu |
| Institution | Shanghai Institute of Materia Medica, China |

**Ranking page:** [Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026](https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026)

**Paper link:** [10.1038/s41401-024-01429-y](https://doi.org/10.1038/s41401-024-01429-y)

## Topics

AlphaFold · G protein-coupled receptor · ligand-bound structures · Experimentally determined structure · structure prediction accuracy · Ligand binding · GPCR structural modeling · Protein structure prediction · binding site prediction · Docking accuracy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026. https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```