# A concerted neuron–astrocyte program declines in ageing and schizophrenia

*PRI Rank #5 · Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 83 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07109-5 |
| Corresponding authors | Emi Ling, Sabina Berretta, Steven A. McCarroll |
| Institution | Broad Institute of MIT and Harvard, United States |

**Ranking page:** [Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026](https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026)

**Paper link:** [10.1038/s41586-024-07109-5](https://doi.org/10.1038/s41586-024-07109-5)

## Topics

single-nucleus RNA sequencing · prefrontal cortex · cortical neurons · cortical astrocytes · synaptic neuron and astrocyte program (SNAP) · latent-factor analysis · synaptic gene expression · cholesterol synthesis · schizophrenia · ageing · Cognitive flexibility · cognitive plasticity · glutamatergic neurons · GABAergic neurons · genetic risk factors for schizophrenia · neuron-astrocyte coordination · synaptic membranes · interindividual variation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026. https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```