# Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling

*PRI Rank #4 · Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 84 |
| Journal | Pharmacological Research |
| Year | 2024 |
| DOI | 10.1016/j.phrs.2024.107363 |
| Corresponding authors | Nadine Jagerovic, Leonardo Pardo, Rafael Franco |
| Institution | Universitat de Barcelona, Spain |

**Ranking page:** [Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026](https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026)

**Paper link:** [10.1016/j.phrs.2024.107363](https://doi.org/10.1016/j.phrs.2024.107363)

## Topics

CB2 cannabinoid receptor · homobivalent ligand · chromenopyrazole · GPCR homodimerization · orthosteric site · membrane-oriented pocket · TM1/7 interface · Gi signaling · β-arrestin recruitment · Conformational change · receptor oligomerization · bivalent ligand pharmacology · protomer binding · TM1/7 interface · dimerization dynamics modulation · enhanced signaling potency · Allosteric site

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026. https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```