# Efficacy and Safety of Xanomeline-Trospium Chloride in Schizophrenia

*PRI Rank #3 · Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 99 |
| Journal | JAMA Psychiatry |
| Year | 2024 |
| DOI | 10.1001/jamapsychiatry.2024.0785 |
| Corresponding authors | Steven M. Paul |
| Institution | Karuna Therapeutics, United States |

**Ranking page:** [Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026](https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026)

**Paper link:** [10.1001/jamapsychiatry.2024.0785](https://doi.org/10.1001/jamapsychiatry.2024.0785)

## Topics

xanomeline-trospium chloride · xanomeline-trospium chloride · M1/M4 muscarinic receptor agonist · Trospium chloride · peripheral muscarinic receptor antagonist · schizophrenia · acute psychosis · PANSS total score · PANSS positive subscale · PANSS negative subscale · PANSS Marder negative factor · Clinical Global Impression-Severity · non-D2 dopamine receptor mechanism · extrapyramidal symptoms · EMERGENT-3 trial · gastrointestinal adverse events · muscarinic receptor activation · Antipsychotic efficacy · weight gain · somnolence

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026. https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```