# A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR

*PRI Rank #20 · Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 41 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-54157-6 |
| Corresponding authors | Dorothée Weikert, Masha Y. Niv, Moran Shalev-Benami |
| Institution | The Hebrew University of Jerusalem, Israel |

**Ranking page:** [Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026](https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026)

**Paper link:** [10.1038/s41467-024-54157-6](https://doi.org/10.1038/s41467-024-54157-6)

## Topics

TAS2R14 · Bitter taste receptors · Bitter taste receptors · flufenamic acid · gustducin · Cryo-electron microscopy · dual binding site · transmembrane bundle · intracellular binding pocket · BRET-based ligand binding assay · GPCR promiscuity · nonsteroidal anti-inflammatory drug · receptor-G protein interface · extraoral TAS2R expression · bitter taste signaling · site-targeted compound design

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026. https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```