# Synthetic GPCRs for programmable sensing and control of cell behaviour

*PRI Rank #18 · Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 44 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08282-3 |
| Corresponding authors | Alice Y. Ting |
| Institution | Stanford University, United States |

**Ranking page:** [Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026](https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026)

**Paper link:** [10.1038/s41586-024-08282-3](https://doi.org/10.1038/s41586-024-08282-3)

## Topics

Synthetic G-protein-coupled receptors · Synthetic G-protein-coupled receptors · antigen-gated receptors · conditional auto-inhibitory domain · nanobody · chimeric antigen receptors · soluble antigens · cell-surface antigens · G-protein activation · transgene expression · T cell migration · macrophage differentiation · therapeutic antibody secretion · neuronal activity inhibition · modular receptor design · drug-controllable receptors · antigen gradient sensing · real-time fluorescence readout

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026. https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```