# RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade

*PRI Rank #15 · Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 45 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-51828-2 |
| Corresponding authors | Antoîne Italiano, Matteo Cereda, David Santamarı́a, Chiara Ambrogio |
| Institution | University of Bordeaux, France |

**Ranking page:** [Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026](https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026)

**Paper link:** [10.1038/s41467-024-51828-2](https://doi.org/10.1038/s41467-024-51828-2)

## Topics

KRAS G12C · sotorasib · adagrasib · non-small cell lung cancer · covalent inhibitors · GDP-bound inactive state · GTP-bound active state · acquired resistance mutations · KRAS-GTP loading · RMC-4998 · RMC-6291 · KRAS G12C(ON) inhibitor · KRAS G12C(OFF) inhibitor · tri-complex inhibitor · adaptive resistance mechanisms · combination therapy · patient-derived models

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026. https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```