# Lactobacillus acidophilus suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma through producing valeric acid

*PRI Rank #7 · Topics and Trends in Most Cited Probiotics and Fermented Foods Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/probiotics-and-fermented-foods/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 63 |
| Journal | EBioMedicine |
| Year | 2024 |
| DOI | 10.1016/j.ebiom.2023.104952 |
| Corresponding authors | Jun Yu |
| Institution | The Chinese University of Hong Kong, China |

**Ranking page:** [Topics and Trends in Most Cited Probiotics and Fermented Foods Papers, Class of 2026](https://pri.pepkio.com/top-papers/probiotics-and-fermented-foods/2026)

**Paper link:** [10.1016/j.ebiom.2023.104952](https://doi.org/10.1016/j.ebiom.2023.104952)

## Topics

Lactobacillus acidophilus · NAFLD-HCC · NAFLD-HCC · valeric acid · diethylnitrosamine · High-fat high-cholesterol diet · Choline-deficient high-fat diet · Germ-free mice · orthotopic allografts · Metabolomics · Liquid chromatography-mass spectrometry · L. acidophilus conditional medium · Intestinal barrier function · GPR41/43 · Rho-GTPase pathway · Probiotic administration · hepatocytic surface receptor · mouse organoids · portal vein metabolites

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Probiotics and Fermented Foods Papers, Class of 2026. https://pri.pepkio.com/top-papers/probiotics-and-fermented-foods/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```