# Trophoblast stem cell-based organoid models of the human placental barrier

*PRI Rank #8 · Topics and Trends in Most Cited Pregnancy and preeclampsia studies Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/pregnancy-and-preeclampsia-studies/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 41 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-45279-y |
| Corresponding authors | Hirokazu Kaji |
| Institution | Tokyo Medical and Dental University, Japan |

**Ranking page:** [Topics and Trends in Most Cited Pregnancy and preeclampsia studies Papers, Class of 2026](https://pri.pepkio.com/top-papers/pregnancy-and-preeclampsia-studies/2026)

**Paper link:** [10.1038/s41467-024-45279-y](https://doi.org/10.1038/s41467-024-45279-y)

## Topics

Trophoblast stem cells · Trophoblast organoids · Chorionic villi · Syncytiotrophoblast · Placental barrier · transplacental passage of xenobiotics · syndecan 1 · Transepithelial/transendothelial electrical resistance · Transepithelial/transendothelial electrical resistance · Human chorionic gonadotropin · apparent permeability coefficients · column-type ST barrier model · compound transfer evaluation · placental toxicity testing · In vitro placental model

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Pregnancy and preeclampsia studies Papers, Class of 2026. https://pri.pepkio.com/top-papers/pregnancy-and-preeclampsia-studies/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```