# Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy

*PRI Rank #7 · Topics and Trends in Most Cited Pregnancy and preeclampsia studies Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/pregnancy-and-preeclampsia-studies/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 42 |
| Journal | Nature Genetics |
| Year | 2024 |
| DOI | 10.1038/s41588-023-01647-w |
| Corresponding authors | Rong Li, Falong Lu, Zhenyu Xiao, Hongmei Wang |
| Institution | Chinese Academy of Sciences, China |

**Ranking page:** [Topics and Trends in Most Cited Pregnancy and preeclampsia studies Papers, Class of 2026](https://pri.pepkio.com/top-papers/pregnancy-and-preeclampsia-studies/2026)

**Paper link:** [10.1038/s41588-023-01647-w](https://doi.org/10.1038/s41588-023-01647-w)

## Topics

Syncytiotrophoblast · Single-nucleus RNA sequencing · single-nucleus ATAC sequencing · human placenta · STB nuclei heterogeneity · developmental trajectories · Trophoblast stem cells · hTSC-derived STB · Gene regulatory networks · Trophoblast organoids · early pregnancy · late pregnancy · transcription factors · STB nuclear lineages · multi-omic profiling · Pregnancy complications

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Pregnancy and preeclampsia studies Papers, Class of 2026. https://pri.pepkio.com/top-papers/pregnancy-and-preeclampsia-studies/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```