# Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells

*PRI Rank #5 · Topics and Trends in Most Cited Pregnancy and preeclampsia studies Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/pregnancy-and-preeclampsia-studies/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 43 |
| Journal | Cell stem cell |
| Year | 2024 |
| DOI | 10.1016/j.stem.2024.07.003 |
| Corresponding authors | Hongmei Wang, Yanling Wang, Ng Shyh‐Chang |
| Institution | State Key Laboratory of Stem Cell and Reproductive Biology, China |

**Ranking page:** [Topics and Trends in Most Cited Pregnancy and preeclampsia studies Papers, Class of 2026](https://pri.pepkio.com/top-papers/pregnancy-and-preeclampsia-studies/2026)

**Paper link:** [10.1016/j.stem.2024.07.003](https://doi.org/10.1016/j.stem.2024.07.003)

## Topics

Acetyl-CoA metabolism · histone acetylation · syncytialization · Trophoblast stem cells · trophoblast differentiation · Syncytiotrophoblast · epigenetic regulation · metabolic control of differentiation · acetyl-CoA availability · chromatin modifications

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Pregnancy and preeclampsia studies Papers, Class of 2026. https://pri.pepkio.com/top-papers/pregnancy-and-preeclampsia-studies/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```