# Birth of protein folds and functions in the virome

*PRI Rank #1 · Topics and Trends in Most Cited Plant Virus Research Studies Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/plant-virus-research-studies/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 76 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07809-y |
| Corresponding authors | Jennifer A. Doudna |
| Institution | Gladstone-UCSF Institute of Data Science and Biotechnology, United States |

**Ranking page:** [Topics and Trends in Most Cited Plant Virus Research Studies Papers, Class of 2026](https://pri.pepkio.com/top-papers/plant-virus-research-studies/2026)

**Paper link:** [10.1038/s41586-024-07809-y](https://doi.org/10.1038/s41586-024-07809-y)

## Topics

viral protein structures · eukaryotic viral species · AlphaFold database · structural homology · innate immunity evasion · RNA ligase T-like phosphodiesterases · cyclic dinucleotides · 3′,3′-cGAMP · 2′,3′-cGAMP · avian poxviruses · bacteriophage · cGAMP hydrolysis · virus-host interactions · protein fold evolution · sequence divergence · structural analogue prediction · immune-activating molecules · phage-encoded proteins · viral protein annotation · virome structural database

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Plant Virus Research Studies Papers, Class of 2026. https://pri.pepkio.com/top-papers/plant-virus-research-studies/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```