# Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance

*PRI Rank #7 · Topics and Trends in Most Cited Plant Pathogens and Fungal Diseases Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/plant-pathogens-and-fungal-diseases/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 38 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-54568-5 |
| Corresponding authors | Michael Bottery, Michael Bromley |
| Institution | University of Manchester, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited Plant Pathogens and Fungal Diseases Papers, Class of 2026](https://pri.pepkio.com/top-papers/plant-pathogens-and-fungal-diseases/2026)

**Paper link:** [10.1038/s41467-024-54568-5](https://doi.org/10.1038/s41467-024-54568-5)

## Topics

Aspergillus fumigatus · Azole resistance · azole fungicides · TR34/L98H · cyp51A · msh6-G233A · DNA mismatch repair · hypermutator · mutation rate elevation · selective sweeps · agricultural antifungals · next-generation antifungals · genetic linkage · fitness cost · environmental selection pressure · cross-resistance · resistance evolution · msh6 variant

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Plant Pathogens and Fungal Diseases Papers, Class of 2026. https://pri.pepkio.com/top-papers/plant-pathogens-and-fungal-diseases/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```