# Drosophila immune cells transport oxygen through PPO2 protein phase transition

*PRI Rank #7 · Topics and Trends in Most Cited Physiological and biochemical adaptations Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/physiological-and-biochemical-adaptations/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 30 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07583-x |
| Corresponding authors | Jiwon Shim |
| Institution | Hanyang University, South Korea |

**Ranking page:** [Topics and Trends in Most Cited Physiological and biochemical adaptations Papers, Class of 2026](https://pri.pepkio.com/top-papers/physiological-and-biochemical-adaptations/2026)

**Paper link:** [10.1038/s41586-024-07583-x](https://doi.org/10.1038/s41586-024-07583-x)

## Topics

Drosophila crystal cells · haemocytes · Prophenoloxidase 2 (PPO2) · PPO2 protein phase transition · PPO2 crystalline structures · tracheal system · oxygen transport · copper-dependent oxygenation · pH-dependent crystal dissolution · carbonic anhydrase · Hypoxia response · arthropod haemocyanin · larval burrowing behavior · internal oxygen homeostasis · myeloid-like immune cells · copper-binding mutant · haemocyte trafficking · normoxic conditions · respiratory organ exposure

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Physiological and biochemical adaptations Papers, Class of 2026. https://pri.pepkio.com/top-papers/physiological-and-biochemical-adaptations/2026. Accessed 2026-10-30.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```