# Two-stage evolution of mammalian adipose tissue thermogenesis

*PRI Rank #18 · Topics and Trends in Most Cited Physiological and biochemical adaptations Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/physiological-and-biochemical-adaptations/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 24 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adg1947 |
| Corresponding authors | Susanne Keipert, Michael J. Gaudry, Martin Jastroch |
| Institution | Stockholm University, Sweden |

**Ranking page:** [Topics and Trends in Most Cited Physiological and biochemical adaptations Papers, Class of 2026](https://pri.pepkio.com/top-papers/physiological-and-biochemical-adaptations/2026)

**Paper link:** [10.1126/science.adg1947](https://doi.org/10.1126/science.adg1947)

## Topics

brown adipose tissue · BAT thermogenesis · Uncoupling protein 1 · Uncoupling protein 1 · marsupials · eutherian mammals · nonthermogenic UCP1 variant · beige adipose tissue · transcriptomic BAT signature · ancestral sequence reconstruction · therian ancestor · common eutherian ancestor · BAT thermogenesis · two-stage evolution · prethermogenic stage · Cold stress · Heat stress · mammalian body temperature regulation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Physiological and biochemical adaptations Papers, Class of 2026. https://pri.pepkio.com/top-papers/physiological-and-biochemical-adaptations/2026. Accessed 2026-10-30.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```