# Lactate dehydrogenase A (LDHA)-mediated lactate generation promotes pulmonary vascular remodeling in pulmonary hypertension

*PRI Rank #16 · Topics and Trends in Most Cited Physiological and biochemical adaptations Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/physiological-and-biochemical-adaptations/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 24 |
| Journal | Journal of Translational Medicine |
| Year | 2024 |
| DOI | 10.1186/s12967-024-05543-7 |
| Corresponding authors | Zhen Zhang, Xingbing Li |
| Institution | The Third People's Hospital of Chengdu, China |

**Ranking page:** [Topics and Trends in Most Cited Physiological and biochemical adaptations Papers, Class of 2026](https://pri.pepkio.com/top-papers/physiological-and-biochemical-adaptations/2026)

**Paper link:** [10.1186/s12967-024-05543-7](https://doi.org/10.1186/s12967-024-05543-7)

## Topics

lactate dehydrogenase A (LDHA) · Lactate accumulation · pulmonary vascular remodeling · pulmonary hypertension · pulmonary artery smooth muscle cells (PASMCs) · Akt signaling pathway · Hypoxia · right ventricular dysfunction · LDHA knockdown · Sugen/hypoxia mouse model · monocrotaline (MCT)-induced rat model · chronic hypoxia-induced mouse model · LDHA inhibitor · Metabolic adaptation · cell proliferation · cell migration · right heart catheterization · Lactate accumulation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Physiological and biochemical adaptations Papers, Class of 2026. https://pri.pepkio.com/top-papers/physiological-and-biochemical-adaptations/2026. Accessed 2026-10-30.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```