# A lethal mitonuclear incompatibility in complex I of natural hybrids

*PRI Rank #1 · Topics and Trends in Most Cited Physiological and biochemical adaptations Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/physiological-and-biochemical-adaptations/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 45 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-023-06895-8 |
| Corresponding authors | Benjamin M. Moran, Molly Schumer |
| Institution | Stanford University, United States |

**Ranking page:** [Topics and Trends in Most Cited Physiological and biochemical adaptations Papers, Class of 2026](https://pri.pepkio.com/top-papers/physiological-and-biochemical-adaptations/2026)

**Paper link:** [10.1038/s41586-023-06895-8](https://doi.org/10.1038/s41586-023-06895-8)

## Topics

mitonuclear incompatibility · Complex I · Complex I · swordtail fish · hybrid incompatibility · reproductive barriers · embryonic lethality · mitochondrial proteome · Allele-specific expression · non-additive genetic interactions · accelerated evolution · introgression · three-gene incompatibility · naturally hybridizing species · complex I function · protein-protein interactions · genetic architecture · interspecific hybrids

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Physiological and biochemical adaptations Papers, Class of 2026. https://pri.pepkio.com/top-papers/physiological-and-biochemical-adaptations/2026. Accessed 2026-10-30.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```