# Gene expression responses of CF airway epithelial cells exposed to elexacaftor/tezacaftor/ivacaftor suggest benefits beyond improved CFTR channel function

*PRI Rank #20 · Topics and Trends in Most Cited Pediatric health and respiratory diseases Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/pediatric-health-and-respiratory-diseases/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 17 |
| Journal | American Journal of Physiology-Lung Cellular and Molecular Physiology |
| Year | 2024 |
| DOI | 10.1152/ajplung.00272.2024 |
| Corresponding authors | Thomas H Hampton |
| Institution | Dartmouth College, United States |

**Ranking page:** [Topics and Trends in Most Cited Pediatric health and respiratory diseases Papers, Class of 2026](https://pri.pepkio.com/top-papers/pediatric-health-and-respiratory-diseases/2026)

**Paper link:** [10.1152/ajplung.00272.2024](https://doi.org/10.1152/ajplung.00272.2024)

## Topics

Elexacaftor/tezacaftor/ivacaftor · CFTR channel function · CF airway epithelial cells (AECs) · gene expression profiling · beta-defensin 1 (hBD-1) · bacterial infection resistance · MMP10 · MMP12 · lung tissue damage · airway inflammation · proinflammatory cytokine secretion · CFTR modulator therapy · Cystic fibrosis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Pediatric health and respiratory diseases Papers, Class of 2026. https://pri.pepkio.com/top-papers/pediatric-health-and-respiratory-diseases/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```