# Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood

*PRI Rank #2 · Topics and Trends in Most Cited Pediatric health and respiratory diseases Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/pediatric-health-and-respiratory-diseases/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 47 |
| Journal | Immunity |
| Year | 2024 |
| DOI | 10.1016/j.immuni.2024.06.010 |
| Corresponding authors | Olaf Perdijk, Tomasz P. Wypych, Benjamin J. Marsland |
| Institution | Monash University, Australia |

**Ranking page:** [Topics and Trends in Most Cited Pediatric health and respiratory diseases Papers, Class of 2026](https://pri.pepkio.com/top-papers/pediatric-health-and-respiratory-diseases/2026)

**Paper link:** [10.1016/j.immuni.2024.06.010](https://doi.org/10.1016/j.immuni.2024.06.010)

## Topics

antibiotic-driven dysbiosis · Microbiome disruption · indole-3-propionic acid · allergic airway inflammation · gut-lung axis · tryptophan metabolism · Gut microbiome · microbial metabolite deficiency · Germ-free mice · asthma pathogenesis · aryl hydrocarbon receptor signaling · Th2 immune response · Airway hyperresponsiveness · fecal metabolomics · Antibiotic use · microbiota-derived indole metabolites · Immune system development · Short-chain fatty acid-producing bacteria · bacterial tryptophan catabolism · mucosal immunity

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Pediatric health and respiratory diseases Papers, Class of 2026. https://pri.pepkio.com/top-papers/pediatric-health-and-respiratory-diseases/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```