# Safety and Immunogenicity of an mRNA-Based hMPV/PIV3 Combination Vaccine in Seropositive Children

*PRI Rank #12 · Topics and Trends in Most Cited Pediatric health and respiratory diseases Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/pediatric-health-and-respiratory-diseases/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 21 |
| Journal | PEDIATRICS |
| Year | 2024 |
| DOI | 10.1542/peds.2023-064748 |
| Corresponding authors | Christine A. Shaw |
| Institution | Moderna, Inc., United States |

**Ranking page:** [Topics and Trends in Most Cited Pediatric health and respiratory diseases Papers, Class of 2026](https://pri.pepkio.com/top-papers/pediatric-health-and-respiratory-diseases/2026)

**Paper link:** [10.1542/peds.2023-064748](https://doi.org/10.1542/peds.2023-064748)

## Topics

mRNA-1653 · Human metapneumovirus · parainfluenza virus type 3 (PIV3) · mRNA-based combination vaccine · membrane-anchored fusion protein antigen design · seropositive pediatric population · phase 1b dose-ranging study · neutralizing antibody titers · preF binding antibody · postF binding antibody · preF-biased antibody response · geometric mean fold-rise · Local adverse reactions · Systemic adverse reactions · prime-boost immunization schedule · vaccine reactogenicity · pediatric respiratory illness prevention · dose-level comparison (10-μg vs 30-μg) · observer-blind placebo-controlled design · immunogenicity in seropositive individuals

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Pediatric health and respiratory diseases Papers, Class of 2026. https://pri.pepkio.com/top-papers/pediatric-health-and-respiratory-diseases/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```