# Metformin targets mitochondrial complex I to lower blood glucose levels

*PRI Rank #18 · Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 42 |
| Journal | Science Advances |
| Year | 2024 |
| DOI | 10.1126/sciadv.ads5466 |
| Corresponding authors | Colleen R. Reczek, Navdeep S. Chandel |
| Institution | Northwestern University, United States |

**Ranking page:** [Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026](https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026)

**Paper link:** [10.1126/sciadv.ads5466](https://doi.org/10.1126/sciadv.ads5466)

## Topics

metformin · mitochondrial complex I · electron transport chain · Glucose-lowering therapy · NDI1 · Saccharomyces cerevisiae internal alternative NADH dehydrogenase · transgenic mice · acute oral administration · antidiabetic mechanism · pharmacologic complex I inhibition · High-fat diet · NADH dehydrogenase · Metabolic homeostasis · mitochondrial respiration

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026. https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```