# Dapagliflozin mitigates cellular stress and inflammation through PI3K/AKT pathway modulation in cardiomyocytes, aortic endothelial cells, and stem cell-derived β cells

*PRI Rank #16 · Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 43 |
| Journal | Cardiovascular Diabetology |
| Year | 2024 |
| DOI | 10.1186/s12933-024-02481-y |
| Corresponding authors | Fatmah R Alsereidi |
| Institution | University of Sharjah, United Arab Emirates |

**Ranking page:** [Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026](https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026)

**Paper link:** [10.1186/s12933-024-02481-y](https://doi.org/10.1186/s12933-024-02481-y)

## Topics

dapagliflozin · SGLT2 inhibitors · PI3K/AKT pathway · cardiomyocytes · aortic endothelial cells · Stem cell-derived islets · isoproterenol-induced hypertrophy · reactive oxygen species · NHE1 · GLUT1 · eNOS · TNFα-induced inflammation · MAFA · NRF2 · NLRP3 inflammasome · GRP78 · MAPK activation · Cardioprotection · endothelial function · Beta cell function

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026. https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```