# SGLT2 inhibitors ameliorate NAFLD in mice via downregulating PFKFB3, suppressing glycolysis and modulating macrophage polarization

*PRI Rank #14 · Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 45 |
| Journal | Acta Pharmacologica Sinica |
| Year | 2024 |
| DOI | 10.1038/s41401-024-01389-3 |
| Corresponding authors | Tianjiao Wei, Rui Wei, Tianpei Hong |
| Institution | Peking University Third Hospital, China |

**Ranking page:** [Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026](https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026)

**Paper link:** [10.1038/s41401-024-01389-3](https://doi.org/10.1038/s41401-024-01389-3)

## Topics

SGLT2 inhibitors · NAFLD · PFKFB3 · Glycolysis · macrophage polarization · dapagliflozin · canagliflozin · Diabetic mouse models · western diet-induced NAFLD · hepatic steatosis · Hepatic fibrosis · M1 macrophage · M2 macrophages · bone marrow-derived macrophages · metabolic reprogramming · RNA sequencing · Seahorse analysis · macrophage-hepatocyte co-culture · lipogenesis · pro-inflammatory cytokines

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026. https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```