# Glucose-sensitive insulin with attenuation of hypoglycaemia

*PRI Rank #13 · Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 45 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08042-3 |
| Corresponding authors | Rita Slaaby |
| Institution | Novo Nordisk, Denmark |

**Ranking page:** [Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026](https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026)

**Paper link:** [10.1038/s41586-024-08042-3](https://doi.org/10.1038/s41586-024-08042-3)

## Topics

NNC2215 · glucose-sensitive insulin · hypoglycaemia attenuation · insulin conjugate · glucose-binding macrocycle · glucoside conjugation · reversible conformational switch · insulin receptor affinity · glucose-responsive bioactivity · Glycemic control · diabetes therapy · glucose concentration range 3-20 mM · in vivo glucose sensing · insulin auto-adjustment

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026. https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```