# Pathogenic hypothalamic extracellular matrix promotes metabolic disease

*PRI Rank #11 · Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026/rank-11*

| Field | Value |
| --- | --- |
| Rank | #11 |
| 18m citations | 48 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07922-y |
| Corresponding authors | Garron T. Dodd |
| Institution | The University of Melbourne, Australia |

**Ranking page:** [Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026](https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026)

**Paper link:** [10.1038/s41586-024-07922-y](https://doi.org/10.1038/s41586-024-07922-y)

## Topics

Arcuate nucleus · perineuronal net · chondroitin sulfate proteoglycan · neuronal insulin resistance · extracellular matrix remodelling · hypothalamic insulin signaling · enzymatic perineuronal net disruption · small molecule perineuronal net disruption · insulin access to brain · Arcuate nucleus · metabolic dysfunction · obesity-induced matrix augmentation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Pancreatic function and diabetes Papers, Class of 2026. https://pri.pepkio.com/top-papers/pancreatic-function-and-diabetes/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```