# Brain clearance is reduced during sleep and anesthesia

*PRI Rank #3 · Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 104 |
| Journal | Nature Neuroscience |
| Year | 2024 |
| DOI | 10.1038/s41593-024-01638-y |
| Corresponding authors | William Wisden, Nicholas P. Franks |
| Institution | Imperial College London, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026)

**Paper link:** [10.1038/s41593-024-01638-y](https://doi.org/10.1038/s41593-024-01638-y)

## Topics

Brain clearance · sleep · anesthesia · metabolite clearance · toxin clearance · fluorescent molecule tracking · molecular movement · male mice · wake state · reduced clearance during sleep · reduced clearance during anesthesia · sleep function · Brain clearance

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```