# Adenosine signalling to astrocytes coordinates brain metabolism and function

*PRI Rank #2 · Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 106 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07611-w |
| Corresponding authors | Shefeeq M. Theparambil, Alexander V. Gourine |
| Institution | University College London, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026)

**Paper link:** [10.1038/s41586-024-07611-w](https://doi.org/10.1038/s41586-024-07611-w)

## Topics

adenosine signalling · astrocytes · brain metabolism · A2B receptors · Astrocyte-neuron interactions · glucose metabolism · lactate release · cAMP-PKA signalling pathway · conditional gene deletion · synaptic function · Synaptic plasticity · hippocampus · recognition memory · sleep · energy demand · neuronal activity-dependent activation · extracellular energy substrates · neuromodulator · brain energy metabolism reprogramming

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```