# Brain region–specific action of ketamine as a rapid antidepressant

*PRI Rank #17 · Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 60 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.ado7010 |
| Corresponding authors | Hailan Hu |
| Institution | Zhejiang University, China |

**Ranking page:** [Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026)

**Paper link:** [10.1126/science.ado7010](https://doi.org/10.1126/science.ado7010)

## Topics

ketamine · NMDA receptor · NMDA receptor antagonism · lateral habenula · hippocampal pyramidal neurons · use-dependent blockade · extrasynaptic NMDAR pool · regional neural activity · conditional NMDAR knockout · serotonin elevation · brain-derived neurotrophic factor · brain-derived neurotrophic factor · depressive-like mice · rapid antidepressant · LHb inactivation · hippocampal activation · brain region selectivity · primary versus secondary drug targets

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```