# Tonic and burst-like locus coeruleus stimulation distinctly shift network activity across the cortical hierarchy

*PRI Rank #10 · Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 72 |
| Journal | Nature Neuroscience |
| Year | 2024 |
| DOI | 10.1038/s41593-024-01755-8 |
| Corresponding authors | Johannes Bohacek, Valerio Zerbi |
| Institution | ETH Zürich, Switzerland |

**Ranking page:** [Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026)

**Paper link:** [10.1038/s41593-024-01755-8](https://doi.org/10.1038/s41593-024-01755-8)

## Topics

locus coeruleus · noradrenaline release · tonic firing · burst-like firing · Optogenetics · photometry · functional magnetic resonance imaging · LC-NA system · cortical hierarchy · network activity · associative processing · sensory processing · astrocytic activity · inhibitory activity · topological configuration · NA release dynamics · brain connectivity

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```