# A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution

*PRI Rank #1 · Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 208 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adk4858 |
| Corresponding authors | Alexander Shapson-Coe, Michał Januszewski, Daniel R. Berger, Viren Jain, Jeff W. Lichtman |
| Institution | Harvard University, United States |

**Ranking page:** [Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026)

**Paper link:** [10.1126/science.adk4858](https://doi.org/10.1126/science.adk4858)

## Topics

nanoscale resolution · human temporal cortex · ultrastructure reconstruction · petavoxel dataset · epileptic focus · glia-to-neuron ratio · oligodendrocytes · deep layer excitatory neurons · dendritic orientation · axonal inputs · Synaptic connectivity · powerful synapses · connectomics · electron microscopy · cubic millimeter tissue volume · cortical cell types · blood vessel reconstruction · synaptic census

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Neuroscience and Neuropharmacology Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/neuroscience-and-neuropharmacology-research/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```