# Neuropeptide signalling orchestrates T cell differentiation

*PRI Rank #4 · Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 54 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08049-w |
| Corresponding authors | Aviv Regev, Arlene H. Sharpe, Vijay K. Kuchroo |
| Institution | Gene Lay Institute of Immunology and Inflammation, United States |

**Ranking page:** [Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026](https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026)

**Paper link:** [10.1038/s41586-024-08049-w](https://doi.org/10.1038/s41586-024-08049-w)

## Topics

Neuropeptide signaling · T cell differentiation · Neuroimmune interaction · neuropeptide receptors · T cell subsets · immune cell regulation · peptidergic signaling · lymphocyte development · neuropeptide-immune axis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026. https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```