# A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut

*PRI Rank #3 · Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 80 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adk1679 |
| Corresponding authors | Yangyang Zhu, Kimberly A. Meerschaert, Christophe Benoıst, Isaac M. Chiu |
| Institution | Harvard Medical School, United States |

**Ranking page:** [Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026](https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026)

**Paper link:** [10.1126/science.adk1679](https://doi.org/10.1126/science.adk1679)

## Topics

Chemogenetic manipulation · Trpv1-expressing neurons · regulatory T cells · Neuroimmune interaction · deep immunophenotyping · microbiome profiling · immunocyte transcriptomics · nitrergic neurons · T helper 17 cells · cholinergic neurons · Sensory neurons · innate lymphocytes · RORγ+ regulatory T cells · Sensory neurons · Calcitonin gene-related peptide (CGRP) · Calcitonin gene-related peptide (CGRP) · nociception · Intestinal barrier

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026. https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```