# Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

*PRI Rank #14 · Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 29 |
| Journal | Nature Neuroscience |
| Year | 2024 |
| DOI | 10.1038/s41593-023-01561-8 |
| Corresponding authors | Wenjuan Tao, Yanghua Tian, Li Bai, Zhi Zhang |
| Institution | University of Science and Technology of China, China |

**Ranking page:** [Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026](https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026)

**Paper link:** [10.1038/s41593-023-01561-8](https://doi.org/10.1038/s41593-023-01561-8)

## Topics

somatosensory cortex · central amygdala · neuropathic pain · peripheral immune response · vagal projections · spleen · Neuroimmune interaction · central-to-peripheral neural pathway · vagus nerve · Neuroimmune interaction · splenic immune regulation · brain-spleen axis · pain-related immunosuppression

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026. https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```