# Pituitary adenylate cyclase-activating polypeptide signalling as a therapeutic target in migraine

*PRI Rank #13 · Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 30 |
| Journal | Nature Reviews Neurology |
| Year | 2024 |
| DOI | 10.1038/s41582-024-01011-4 |
| Corresponding authors | Messoud Ashina |
| Institution | Copenhagen University Hospital-Rigshospitalet, Denmark |

**Ranking page:** [Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026](https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026)

**Paper link:** [10.1038/s41582-024-01011-4](https://doi.org/10.1038/s41582-024-01011-4)

## Topics

PACAP · PACAP · migraine · Neuropeptide signaling · PAC1 receptor · VPAC receptors · Calcitonin gene-related peptide (CGRP) · Calcitonin gene-related peptide (CGRP) · trigeminovascular system · vasodilation · mast cell degranulation · PACAP inhibition · monoclonal antibodies · migraine prevention · headache disorders · neuropeptide therapeutic targets

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026. https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```