# The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron

*PRI Rank #11 · Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026/rank-11*

| Field | Value |
| --- | --- |
| Rank | #11 |
| 18m citations | 33 |
| Journal | Science Translational Medicine |
| Year | 2024 |
| DOI | 10.1126/scitranslmed.adp5765 |
| Corresponding authors | Kyle W. Sloop |
| Institution | Eli Lilly and Company, United States |

**Ranking page:** [Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026](https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026)

**Paper link:** [10.1126/scitranslmed.adp5765](https://doi.org/10.1126/scitranslmed.adp5765)

## Topics

Orforglipron · GLP-1 receptor · nonpeptide agonists · GLP-1 receptor · Type 2 diabetes mellitus · obesity · competition binding experiments · intrinsic efficacy · β-arrestin · receptor occupancy · CRISPR-Cas9 gene editing · Glp1r S33W · semaglutide · Diet-induced obesity · oral bioavailability · target engagement · Signal transduction · Glucose tolerance · peptide receptors

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026. https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```