# A µ-opioid receptor modulator that works cooperatively with naloxone

*PRI Rank #10 · Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 33 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07587-7 |
| Corresponding authors | Jay P. McLaughlin, Susruta Majumdar, Brian K. Kobilka |
| Institution | Stanford University, United States |

**Ranking page:** [Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026](https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026)

**Paper link:** [10.1038/s41586-024-07587-7](https://doi.org/10.1038/s41586-024-07587-7)

## Topics

μ-opioid receptor · opioid receptor modulator · naloxone · synergistic drug interaction · Allosteric modulation · Opioid antagonism · Opioid antagonism · receptor pharmacology · positive allosteric modulator · synergistic drug interaction

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026. https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```