# Neuronal substance P drives metastasis through an extracellular RNA–TLR7 axis

*PRI Rank #1 · Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 127 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07767-5 |
| Corresponding authors | Sohail F. Tavazoie |
| Institution | The Rockefeller University, United States |

**Ranking page:** [Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026](https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026)

**Paper link:** [10.1038/s41586-024-07767-5](https://doi.org/10.1038/s41586-024-07767-5)

## Topics

Substance P · metastasis · extracellular RNA · Toll-like receptor 7 · Neuronal modulation · Tumor innervation · neuropeptide · Toll-like receptor 7 · cancer progression · Neuroimmune interaction · RNA-mediated signaling · Sensory neurons · tumor microenvironment · Neurokinin 1 receptor (NK1R) · extracellular RNA · innate immunity

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Neuropeptides and Animal Physiology Papers, Class of 2026. https://pri.pepkio.com/top-papers/neuropeptides-and-animal-physiology/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```