# Mechanosensitive channels TMEM63A and TMEM63B mediate lung inflation–induced surfactant secretion

*PRI Rank #17 · Topics and Trends in Most Cited Neonatal Respiratory Health Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/neonatal-respiratory-health-research/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 31 |
| Journal | Journal of Clinical Investigation |
| Year | 2024 |
| DOI | 10.1172/jci174508 |
| Corresponding authors | Gui-Lan Chen |
| Institution | Institute of Cardiovascular Research, China |

**Ranking page:** [Topics and Trends in Most Cited Neonatal Respiratory Health Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/neonatal-respiratory-health-research/2026)

**Paper link:** [10.1172/jci174508](https://doi.org/10.1172/jci174508)

## Topics

TMEM63A · TMEM63B · mechanosensitive channels · pulmonary surfactant secretion · Alveolar type 2 cells · Alveolar type 2 cells · lamellar body · mechanical stretch sensing · Lung aeration · atelectasis · respiratory failure · ATP release · Ca2+ signaling · exocytic fusion · lysosome-related organelle · limiting membrane · Respiratory distress syndrome · first breath · alveolar surface tension

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Neonatal Respiratory Health Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/neonatal-respiratory-health-research/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```