# Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis

*PRI Rank #18 · Topics and Trends in Most Cited Mycobacterium research and diagnosis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/mycobacterium-research-and-diagnosis/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 22 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07206-5 |
| Corresponding authors | Elizabeth A. Campbell, Jeremy M. Rock |
| Institution | The Rockefeller University, United States |

**Ranking page:** [Topics and Trends in Most Cited Mycobacterium research and diagnosis Papers, Class of 2026](https://pri.pepkio.com/top-papers/mycobacterium-research-and-diagnosis/2026)

**Paper link:** [10.1038/s41586-024-07206-5](https://doi.org/10.1038/s41586-024-07206-5)

## Topics

rifampicin resistance · Mycobacterium tuberculosis · compensatory mutations · fitness cost · RNA polymerase · NusG · CRISPR interference · comparative functional genomics · RNAP pausing · NusG-RNAP interface · positive selection · drug-resistant strains · transcription factor · clinical isolates · pro-pausing function

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Mycobacterium research and diagnosis Papers, Class of 2026. https://pri.pepkio.com/top-papers/mycobacterium-research-and-diagnosis/2026. Accessed 2026-07-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```