# Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial

*PRI Rank #1 · Topics and Trends in Most Cited Mosquito-borne diseases and control Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/mosquito-borne-diseases-and-control/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 204 |
| Journal | The Lancet |
| Year | 2024 |
| DOI | 10.1016/s0140-6736(23)02511-4 |
| Corresponding authors | Adrian V. S. Hill |
| Institution | University of Oxford, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited Mosquito-borne diseases and control Papers, Class of 2026](https://pri.pepkio.com/top-papers/mosquito-borne-diseases-and-control/2026)

**Paper link:** [10.1016/s0140-6736(23)02511-4](https://doi.org/10.1016/s0140-6736(23)02511-4)

## Topics

R21/Matrix-M · malaria vaccine · African children · phase 3 trial · Double-blind randomized placebo-controlled trial · vaccine efficacy · vaccine safety · Matrix-M adjuvant · Plasmodium falciparum · clinical malaria · seasonal malaria transmission · parasitaemia · vaccination schedule · booster dose · protective efficacy · adverse events · Immunogenicity · anti-circumsporozoite antibodies

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Mosquito-borne diseases and control Papers, Class of 2026. https://pri.pepkio.com/top-papers/mosquito-borne-diseases-and-control/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```