# Impact of soluble BCMA and non–T-cell factors on refractoriness to BCMA-targeting T-cell engagers in multiple myeloma

*PRI Rank #8 · Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 54 |
| Journal | Blood |
| Year | 2024 |
| DOI | 10.1182/blood.2024026212 |
| Corresponding authors | Holly Lee |
| Institution | University of Calgary, Canada |

**Ranking page:** [Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026)

**Paper link:** [10.1182/blood.2024026212](https://doi.org/10.1182/blood.2024026212)

## Topics

soluble BCMA · BCMA-targeting T-cell engagers · teclistamab · multiple myeloma · CAR T-cell therapy · primary refractoriness · BCMA expression · tumor burden · GPRC5D · gamma secretase inhibitors · whole-genome sequencing · in vitro cytotoxicity assay · TCE dose intensity · soluble BCMA · adoptive T-cell therapy · Predictive biomarker · correlative patient analysis · high-risk disease features · anti-BCMA therapy resistance · baseline sBCMA threshold

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```