# A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses

*PRI Rank #19 · Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 42 |
| Journal | Nature Immunology |
| Year | 2024 |
| DOI | 10.1038/s41590-024-01880-3 |
| Corresponding authors | Paolo Casali |
| Institution | The University of Texas Long School of Medicine, United States |

**Ranking page:** [Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026)

**Paper link:** [10.1038/s41590-024-01880-3](https://doi.org/10.1038/s41590-024-01880-3)

## Topics

Humanized mouse model · Kit W-41J mutant immunodeficient mice · human cord blood CD34+ cell engraftment · 17β-estradiol conditioning · genetic myeloablation · non-γ-irradiation conditioning · marginal zone B cells · germinal center B cells · T follicular helper cells · Peyer's patches reconstitution · human thymic epithelial cells · immune repertoire · somatic hypermutation · class switch recombination · memory B cells · flagellin immunization · Pfizer-BioNTech vaccine · SARS-CoV-2 Spike S1 receptor-binding domain neutralizing antibodies · pristane-induced lupus autoimmunity · APRIL BAFF TGF-β IL-4 IFN-γ cytokine profile

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```